A recent study in the Journal of Experimental Medicine shows why nearly all obese patients do not go on to develop type 2 diabetes.
The research was conducted at Oregon State University.
“Using multiorgan network and transkingdom analyses, we found that microbiota-dependent impairment of OXPHOS/mitochondria in white adipose tissue (WAT) plays a primary role in regulating systemic glucose metabolism,” the authors explained in a news release.
“Our experiments and analysis predict that a high-fat/high-sugar diet primarily acts in white adipose tissue by driving microbiota-related damage to the energy synthesis process, leading to systemic insulin resistance.”
“Treatments that modify a patient’s microbiota in ways that target insulin resistance in adipose tissue macrophage cells could be a new therapeutic strategy for type 2 diabetes.”
The study involved the development of a computational method known as transkingdom network analysis and experimentation on rodents, including examining on the molecular signature of white adipose tissue macrophages among obese patients.