Previous research has shown that herpes virus infection may lead to plaques in the brain associated with Alzheimer’s disease (AD). New research by Tufts University unveiled that two common compounds could reduce the formation of plaques.
The findings can be read in Free Radical Biology and Medicine.
The two compounds are resveratrol and green tea catechins. The discovery came about after testing 21 different compounds in Alzheimer’s-afflicted neural cells in a laboratory.
“Here, we describe the use of 2D and 3D tissue culture models of herpesvirus-induced AD, which recapitulate hallmark disease features of plaque formation, gliosis, neuroinflammation, and impaired neuronal signaling, to screen a panel of 21 medications, supplements, and nutraceuticals with purported neuroprotective benefits,” the authors explained in their journal article.
“This study establishes a simple platform for rapidly screening and characterizing AD compounds of interest in 2D and 3D human cortical tissue models representing physiologically relevant disease features.”