New research conducted by experts at Linköping University in Sweden unveiled that changes in the brain long before symptoms of neurodegeneration appear can be studies early in the disease process.
“Many researchers and clinicians take the position that therapies for neurodegenerative diseases must be applied at very early stages, even before clinical signs emerge, to provide any benefit,” according to one research of two studies conducted at Linköping University, in a news release. “This is why it’s important to understand what is happening in the earliest stages of the disease.”
“In our studies, we see coordinated changes in gene expression in the very early stages of the diseases, as if the cells are trying to change something in their biology to fight off the disease,” the researcher also explained in a news release.
As part of both studies, researchers used a method capable of following the ribosomes in one specific cell type and establishing activity in the cell at a particular moment.
The studies were published in PLOS Pathogens and Life Science Alliance.
The research was published online on August 12, 2022.