A commonly used class of medications known as corticosteroids, specifically the use of prednisone, may improve the likelihood.
The study was published in the Journal of Experimental Medicine.
“Here we report that in mice with diet-induced obesity, intermittent once-weekly prednisone increased total and high-molecular weight adiponectin levels and improved exercise tolerance and energy expenditure,” according to the study’s authors.
“These effects were dependent upon adiponectin, as shown by genetic ablation of the adipokine.”
“What is exciting to me about this work is the finding that a simple change in the dosing frequency can transform glucocorticoid drugs from inducers to preventers of obesity.” said co-author Mattia Quattrocelli.
The findings showed how subjects tested were administered a high-fat diet and upon receiving prednisone once a week, their exercise endurance increased and weight loss was facilitated.
