Mental DailyMental Daily
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Aa
Mental Daily
Aa
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • Opinion
Search
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Follow US
  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store
© 2024 - Mental Daily. All Rights Reserved.
Clinical

New research may result in more precise diagnoses and interventions of Alzheimer’s

Staff Writer
Staff Writer 4 years ago
Updated 2022/01/08 at 11:59 PM
Share
SHARE

Researchers with Case Western Reserve University looked at the brain samples of 40 participants who suffered from Alzheimer’s disease (AD) upon becoming deceased.

Published in Science Translational Medicine, their recent study determined that the cores of tau protein particles have distinct structural organizations.

According to researchers, a link was found between strains of misshapen tau protein and accelerated cognitive decline. The new findings may lead to more precise diagnoses and interventions for patients with Alzheimer’s.

“Using sensitive biophysical methods in 40 patients with AD and markedly different disease durations, we identified populations of distinct TAU particles that differed in size, structural organization, and replication rate in vitro and in cell assay,” the authors explained in their findings.

“The rapidly replicating, distinctly misfolded TAU conformers found in rapidly progressive AD were composed of ~80% misfolded four-repeat (4R) TAU and ~20% of misfolded 3R TAU isoform with the same conformational signatures,” the authors also determined.

“These biophysical observations suggest that distinctly misfolded population of 4R TAU conformers drive the rapid decline in AD and imply that effective therapeutic strategies might need to consider not a singular species but a cloud of differently misfolded TAU conformers.”

You Might Also Like

Study explores victim-blaming, manipulation, and denial as tactics used by terrorists

Study finds people change their mind about conspiracy theories but not often

Study finds majority of prisoners receive no visitors, possibly affecting recidivism

Dementia risk factors differ by ethnicity, according to new research

Researchers investigate how endocannabinoids regulate the brain’s stress response

TAGGED: Alzheimer's disease, cognition, neuroscience
Staff Writer January 8, 2022
Share this Article
Facebook Twitter Whatsapp Whatsapp Email Print
Previous Article Post-natal exposure to household pesticides may harm infants’ gross motor development
Next Article Survey finds three-in-ten Americans are avid readers of e-books

Recommended

Clinical

Study explores victim-blaming, manipulation, and denial as tactics used by terrorists

1 Min Read
Social

Study finds people change their mind about conspiracy theories but not often

2 Min Read
Clinical

Study finds majority of prisoners receive no visitors, possibly affecting recidivism

2 Min Read
Clinical

Dementia risk factors differ by ethnicity, according to new research

2 Min Read
//

We are a trusted online source for research news and resources on all aspects of the mind and human behavior.

Verticals

  • Clinical
  • Health
  • Social
  • I/O
  • Opinion

Social

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Links

  • About
  • Contact
  • The Editor
  • Terms & Conditions
  • Privacy Policy
  • Mental Health
Follow US

© 2024 Mental Daily. All Rights Reserved.

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?