Newer generation antidepressants are not much effective in children and adolescents

Based on CDC estimates from a 2020 report, antidepressant use is on the rise, with as many as 25 percent of adolescents have experienced a depressive episode in the past.

In a new study, it was concluded that antidepressants only minimally improved depressive symptoms in children and adolescents.

For the study, several databases were evaluated including the Cochrane Common Mental Disorders Specialised Register, involving six to 18 years olds.

From the study: “Overall, methodological shortcomings of the randomised trials make it difficult to interpret the findings with regard to the efficacy and safety of newer antidepressant medications.”

“Findings suggest that most newer antidepressants may reduce depression symptoms in a small and unimportant way compared with placebo,” the authors determined.

“Consideration of psychotherapy, particularly cognitive behavioural therapy, as per guideline recommendations, remains important.”

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