Mental DailyMental Daily
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Aa
Mental Daily
Aa
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • Opinion
Search
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Follow US
  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store
© 2024 - Mental Daily. All Rights Reserved.
Clinical

Microglia may decrease the severity of epileptic seizures

Staff Writer
Staff Writer 5 years ago
Updated 2020/08/29 at 12:02 AM
Share
SHARE

Published in the American Journal of Physiology-Cell Physiology, researchers associated with the American Physiology Society concluded that microglia may be beneficial in reducing the severity of epileptic seizures.

“Little is known whether microglia take part in the regulation of acute neuronal excitation and ongoing epileptic behaviors,” according to researchers.

“We proposed that if microglia are innately ready to respond to epileptic overexcitation, depletion of microglia might alter neuronal excitability and severity of acute epileptic seizures.”

Based on their findings, initiated in mouse models, researchers indicated that microglia may serve sort of like a protective role against seizures, protecting neurons from excitotoxicity-induced degeneration. Depletion of microglia was synonymous with increased acute seizures and hippocampal neuronal degeneration.

“We found that microglia depletion by PLX3397, an inhibitor of CSF1R, exacerbates seizure severity and excitotoxicity-induced neuronal degeneration, indicating that microglia are rapidly responsive to the change of excitation/inhibition homeostasis and participate in the protection of neurons from overexcitation,” the co-authors concluded in their findings.

You Might Also Like

Study explores victim-blaming, manipulation, and denial as tactics used by terrorists

Study finds majority of prisoners receive no visitors, possibly affecting recidivism

Dementia risk factors differ by ethnicity, according to new research

Researchers investigate how endocannabinoids regulate the brain’s stress response

Study shows the risk of eating disorders may be lower among vegans

TAGGED: microglia, physiology, epilepsy
Staff Writer August 28, 2020
Share this Article
Facebook Twitter Whatsapp Whatsapp Email Print
Previous Article The American public’s confidence in scientists has maintained stability over the years
Next Article Researchers find associations between frequent nightmares and cardiovascular disease in military veterans

Recommended

Clinical

Study explores victim-blaming, manipulation, and denial as tactics used by terrorists

1 Min Read
Clinical

Study finds majority of prisoners receive no visitors, possibly affecting recidivism

2 Min Read
Clinical

Dementia risk factors differ by ethnicity, according to new research

2 Min Read
Clinical

Researchers investigate how endocannabinoids regulate the brain’s stress response

2 Min Read
//

We are a trusted online source for research news and resources on all aspects of the mind and human behavior.

Verticals

  • Clinical
  • Health
  • Social
  • I/O
  • Opinion

Social

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Links

  • About
  • Contact
  • The Editor
  • Terms & Conditions
  • Privacy Policy
  • Mental Health
Follow US

© 2024 Mental Daily. All Rights Reserved.

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?