Experts at Uppsala University have demonstrated that the metabolism in people with type 2 diabetes (T2D) and prediabetes (PD) is more dysregulated than previously believed.
The study was published in Cell Reports Medicine.
The research involved the comparing of proteins in samples from patients with prediabetes and type 2 diabetes.
The research team uncovered highly disturbed metabolism in distinct pathways in the organs examined and at different stages of disease.
“Overall, our findings suggest inflammatory, immune and vascular impairments in pancreatic islets as potentially causal factors of insufficient insulin production and increased glucagon levels in the early stages of T2D,” the authors wrote in their findings. “In contrast alterations in lipid metabolism and mitochondrial function in the liver and VAT/muscle, respectively, became evident later in manifest T2D.”
“This first multi-tissue proteomic map indicates the temporal order of tissue-specific metabolic dysregulation in T2D development.”
