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Clinical

New study links 27 genetic risk variants to ADHD

Staff Writer
Staff Writer 2 years ago
Updated 2023/02/10 at 9:27 AM
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A genome-wide association study meta-analysis of ADHD was presented as part of a study in Nature Genetics. The research identified 27 genetic risk variants linked to ADHD.

In the research, more than 38,000 people with a history of ADHD, in addition to 186,843 controls, were included.

According to the study: ” Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons.”

“In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders.”

“In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention.”

Photo: Getty Images

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TAGGED: adhd, Genetics
Staff Writer February 9, 2023
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