Experts at the University of Alberta have unveiled that risk factors associated with Alzheimer’s disease differs greatly between biological males and females.
The study was published in the Journal of Alzheimer’s Disease.
The data of more than 600 older adults was analyzed by the researchers. The data was gathered from the Victoria Longitudinal Study.
Two risk factors were considered: a gene called bridging integrator 1 (BIN1) and pulse pressure for measuring vascular health.
“We examine BIN1 risk for a moderating role with vascular health (pulse pressure; PP) and sex in predictions of episodic memory trajectories in asymptomatic aging adults,” the report reads.
“We observed a novel interaction whereby BIN1 (linked with tauopathy in AD) and sex sequentially moderated a benchmark PP prediction of differential memory decline in asymptomatic aging. This multi-modal biomarker interaction approach, disaggregated by sex, can be an effective method for enhancing precision of AD genetic risk”
