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Clinical

Type 2 diabetes may lead to a significant increase in brain aging and cognitive decline

Staff Writer
Staff Writer 8 months ago
Updated 2022/05/25 at 2:56 AM
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A new study in eLife has examined type 2 diabetes mellitus (T2DM) and brain aging.

The research was based on data available from the UK Biobank, including neuroimaging and cognitive data.

“Our findings were complemented by meta-analyses of published reports with cognitive or neuroimaging measures for T2DM and healthy controls (HC),” according to the study’s authors.

“We also evaluated in a cohort of T2DM diagnosed individuals using UK Biobank how disease chronicity and metformin treatment interact with the identified neurocognitive effects.”


The findings point to a neurocognitive impact with T2DM resulting in marked acceleration of normal brain aging.

“T2DM gray matter atrophy occurred approximately 26% ± 14% faster than seen with normal aging; disease duration was associated with increased neurodegeneration,” the study uncovered.

“Mechanistically, our results suggest a neurometabolic component to brain aging. Clinically, neuroimaging-based biomarkers may provide a valuable adjunctive measure of T2DM progression and treatment efficacy based on neurological effects.”

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TAGGED: cognition, memory, neurodegeneration, type 2 diabetes
Staff Writer May 24, 2022
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Previous Article Researchers find that lessening screen time increases physical activity in children
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