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Health

Study unveils new approach to preserve insulin-producing cells associated with diabetes

Staff Writer
Staff Writer 5 months ago
Updated 2022/04/01 at 2:00 AM
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A new antidiabetic drug that preserves the activity of insulin-producing beta cells and prevents high blood glucose was highlighted in Science Translational Medicine.

“We postulated that this state mediates a hypoxic phenotype driven by hypoxia-inducible factor–1α (HIF-1α) and that treatment with the HIF-1α inhibitor PX-478 would improve β cell function,” the study states.

“Our studies showed that the HIF-1α protein was present in pancreatic β cells of diabetic mouse models.”

The study, initiated on rodents, suggests that the HIF-1α inhibitor PX-478 may act to preserve β cell function, thus functioning as diabetes therapy.

“Our study shows that this leads to a hypoxic state that increases the levels of HIF-1alpha protein, which in turn reduces beta cell activity. By treating diabetic mice with the HIF-1alpha inhibitor PX-478, we successfully decreased their blood glucose levels,” one expert from Karolinska Institutet explained in a news release.

The study was published online on March 30th, 2022.

Photo: iStock

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TAGGED: glucose, diabetes
Staff Writer March 31, 2022
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