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Clinical

Study identifies new mechanism associated with long-term memory storage linked to cognitive disease

Staff Writer
Staff Writer 11 months ago
Updated 2022/03/24 at 2:24 AM
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Researchers from the University of Iowa uncovered a new mechanism associated with long-term memory storage that may be linked to cognitive deficits seen in Alzheimer’s disease.

As mentioned in the journal Science Advances, a novel protein folding mechanism situated in the endoplasmic reticulum fundamental to long-term memorical storage was identified.

“Fundamental studies have shown that a set of transcriptional regulatory proteins of the nuclear receptor 4a (Nr4a) family serve as molecular switches for long-term memory,” according to the study’s authors.

“Here, we show that Nr4a proteins regulate the transcription of genes encoding chaperones that localize to the endoplasmic reticulum.”


From the study: “Our findings establish a unique molecular concept underlying long-term memory and provide insights into the mechanistic basis of cognitive deficits in dementia.”

Photo: Getty Images

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TAGGED: Nr4a, cognition, memory
Staff Writer March 23, 2022
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