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Clinical

Researchers unveiled a drug candidate able to raise insulin secretion in type 2 diabetes

Staff Writer
Staff Writer 2 years ago
Updated 2022/03/31 at 4:08 AM
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In Diabetes, experts at Lund University unveiled a drug candidate able to raise insulin secretion in type 2 diabetes (T2D).

Their research centered on a specific microRNA known as miR-200c. The findings shows that the levels of miR-200c varys between people with type 2 diabetes and without.

“Here we report increased expression of miR-200c in islets from T2D as compared with nondiabetic (ND) donors and display results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c,” the authors explained in their findings.

“In this study we have identified miR-200c as an miRNA differentially upregulated in human islets from T2D donors. Moreover, we identified ETV5 as an interesting novel target of miR-200c in human islets, together with the identification of previous targets validated in rodent models such as JAZF1.”

“Our data reveal a vital role of the miR-200c–ETV5 axis in β-cell dysfunction and pathophysiology of T2D,” the authors determined.

Photo: iStockphoto

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TAGGED: mIR-200c, type 2 diabetes
Staff Writer March 30, 2022
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