Mental DailyMental Daily
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Aa
Mental Daily
Aa
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • Opinion
Search
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Follow US
  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store
© 2022 - Mental Daily. All Rights Reserved.
Clinical

Research explores the long-term use of diazepam and its subsequent onset of cognitive decline

Staff Writer
Staff Writer 11 months ago
Updated 2022/03/04 at 1:36 AM
Share
SHARE

The common use of anxiolytic drugs like diazepam has been been established for the treatment of anxiety disorders. While its use is considered relatively safe for short-term use, its long-term use may yield problematic outcomes.

According to Nature Neuroscience, long-term use of diazepam may result in physical dependency and cognitive impairments among older people.

The study’s authors explain how immune cells of the brain called microglia play a major role in degrading and recycling synapses during brain development and in cognitive disorders upon use of diazepam.

In rodents, experimentation shows that diazepam use could impair the structural plasticity of dendritic spines, resulting in cognitive impairment.


“Diazepam induces these deficits via the mitochondrial 18 kDa translocator protein (TSPO), rather than classical γ-aminobutyric acid type A receptors, which alters microglial morphology, and phagocytosis of synaptic material,” the study states.

“Collectively, our findings demonstrate a mechanism by which TSPO ligands alter synaptic plasticity and, as a consequence, cause cognitive impairment.”

You Might Also Like

Recalling sexual victimization may not be impaired by moderate alcohol intoxication

Research shows obesity-related neurodegeneration is similar to Alzheimer’s disease

New study explores test that can detect Alzheimer’s years before diagnosis

New research explores the association between viral infection and Alzheimer’s disease

Prenatal exposure to pollution may be linked to lower cognitive scores in infants

TAGGED: benzodiazepines, diazepam, cognition
Staff Writer March 3, 2022
Share this Article
Facebook Twitter Whatsapp Whatsapp Email Print
Previous Article How a keto diet may alleviate the symptoms of multiple sclerosis
Next Article Agreeableness personality trait regarded as beneficial for general life success

Recommended

Clinical

Recalling sexual victimization may not be impaired by moderate alcohol intoxication

2 Min Read
Clinical

Research shows obesity-related neurodegeneration is similar to Alzheimer’s disease

1 Min Read
Clinical

New study explores test that can detect Alzheimer’s years before diagnosis

1 Min Read
Health

New research explores the association between viral infection and Alzheimer’s disease

1 Min Read
//

We are a trusted online source for research news and resources on all aspects of the mind and human behavior.

Verticals

  • Clinical
  • Health
  • Social
  • I/O
  • Opinion

Social

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Links

  • About
  • Contact
  • The Editor
  • Terms & Conditions
  • Privacy Policy
Follow US

© 2022 Mental Daily. All Rights Reserved.

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?