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Clinical

How skin biopsy may result in early identification and diagnosis of Parkinson’s disease

Staff Writer
Staff Writer 10 months ago
Updated 2022/03/20 at 12:38 AM
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A new study in the Journal of Parkinson’s Disease uncovered how neuronal deposits of phosphorylated alpha-synuclein (p-syn) in the body of patients may result in the early detection and diagnosis of the disease.

For the study, researchers sought to assess skin p-syn deposits among patients with parkinsonism as a result of tauopathy and Parkinson’s disease.

More than 20 patients were recruited for the research. 18 involved a diagnosis for progressive supranuclear palsy, 8 of corticobasal syndrome, 26 of Parkinson’s disease, and 26 served as part of a healthy control group.

Skin biopsy was conducted among all of the participants.


What researchers determined: “The detection of skin p-syn deposits may help in the differential diagnosis of parkinsonism.”

“Indeed, in this study, all PD patients and only two out of 26 with a clinical diagnosis of PSP/CBS had skin p-syn deposits,” the authors also concluded. “Furthermore, these two patients showed clinical features that could suggest an atypical synucleinopathy presentation or a mixed pathology.”

Photo: Shutterstock

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TAGGED: skin biopsy, parkinson's disease
Staff Writer March 19, 2022
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