As published in JNeurosci, the proper treatment of developmental disorders may be the result of timing. In a recent study, it was found that inhibiting a specific signaling pathway early in life may inhibit symptoms of autism in rodents.
“In this study, we identify a critical period for the development of ASD-relevant behaviors in a cerebellar male mouse model of Tuberous Sclerosis Complex (TSC), by using the mechanistic target of rapamycin (mTOR) inhibitor, rapamycin, to pharmacologically inhibit dysregulated downstream signaling,” the authors explained in the published study.
“We find independent critical periods during which abnormal ASD-relevant behaviors develop for the two core ASD diagnostic criteria – social impairments and behavioral flexibility – and delineate an anatomical, physiological, and behavioral framework.”
Researchers found the results to be insightful in understanding the genetic mechanisms underlying the timing of autistic behaviors.
“These findings not only further our understanding of the genetic mechanisms underlying the timing of ASD-relevant behaviors but also have the capacity to inform potential therapies to optimize treatment interventions.”