Mental DailyMental Daily
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Aa
Mental Daily
Aa
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • Opinion
Search
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • My Bookmarks
Follow US
  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store
© 2022 - Mental Daily. All Rights Reserved.
Clinical

New research explains the implications of Parkinson’s disease treatment L-dopa

Staff Writer
Staff Writer 1 year ago
Updated 2022/01/20 at 10:46 PM
Share
SHARE

New findings released in ACS Chemical Neuroscience may have uncovered why the drug therapy l-3,4-Dihydroxyphenylalanine (l-DOPA) used to treat Parkinson’s disease decreases in efficacy over time.

Experts at the University of California, Irvine turned to the effects of decreased L-dopa efficacy, which results in a higher risk of dyskinesia.

“In this study, we used the surface plasmon resonance (SPR) technique to examine the binding properties of l-DOPA to Scn,” according to UC experts.

“Our analysis of the binding properties of l-DOPA precursors and metabolites indicates that the catechol group is necessary but not sufficient to form a stable complex with Scn,” the experts asserted in their findings.


The study explained how the conjunctive activity between L-dopa and siderocalin in the presence of iron may lead to cellular iron excessivity that ultimately results in the onset of dyskinesia.

“This small L-dopa molecule is certainly mysterious. We’re interested in unlocking L-dopa mysteries and, in particular, understanding how it acts as such a magic therapeutic agent and, at the same time, contributes to disease progression,” said one co-author of the study in a news release.

“The formation of the L-dopa-siderocalin complex may play a role in decreasing efficacy by reducing the amount of free L-dopa available for dopamine synthesis in the brain.”

The study was authored by Sammy Alhassen, Mehmet Senel, and Amal Alachkar.

Photo: Bigstock

You Might Also Like

New study explores test that can detect Alzheimer’s years before diagnosis

Prenatal exposure to pollution may be linked to lower cognitive scores in infants

Researchers unveil new drug candidate to help treat adrenoleukodystrophy

New research finds Alzheimer’s risk factors affect males and females very differently

Study establishes critical role in regulating excessive folding of gyri in brain

TAGGED: siderocalin, L-DOPA, parkinson's disease
Staff Writer January 20, 2022
Share this Article
Facebook Twitter Whatsapp Whatsapp Email Print
Previous Article British study finds increased alcohol purchasing during COVID-19 lockdowns
Next Article Feeding problems may serve as an indicator of developmental delay in early childhood

Recommended

Clinical

New study explores test that can detect Alzheimer’s years before diagnosis

1 Min Read
Clinical

Prenatal exposure to pollution may be linked to lower cognitive scores in infants

1 Min Read
Clinical

Researchers unveil new drug candidate to help treat adrenoleukodystrophy

1 Min Read
Clinical

New research finds Alzheimer’s risk factors affect males and females very differently

1 Min Read
//

We are a trusted online source for research news and resources on all aspects of the mind and human behavior.

Verticals

  • Clinical
  • Health
  • Social
  • I/O
  • Opinion

Social

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Links

  • About
  • Contact
  • The Editor
  • Terms & Conditions
  • Privacy Policy
Follow US

© 2022 Mental Daily. All Rights Reserved.

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?