Mental DailyMental Daily
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • The Discussion
    • My Bookmarks
Aa
Mental Daily
Aa
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • Opinion
Search
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • The Discussion
    • My Bookmarks
Follow US
  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store
© 2022 - Mental Daily. All Rights Reserved.
Clinical

Mutations of autism-linked Dyrk1a gene may affect the brain’s growth signaling network

Staff Writer
Staff Writer 1 year ago
Updated 2021/05/12 at 6:18 PM
Share
SHARE

In a rodent model, damage to the gene Dyrk1a was associated with unusual growth-factor signaling and other factors, resulting in autism-like behaviors, according to researchers at Scripps Research Institute.

The findings were publicized in the journal Biological Psychiatry.

“We generated a conditional mouse model using Emx1-cre, including conditional heterozygous and homozygous knockouts, to investigate the necessity of Dyrk1a in the cortex during development,” the study reads.

“We used unbiased, high-throughput phosphoproteomics to identify dysregulated signaling mechanisms in the developing Dyrk1a mutant cortex as well as classic genetic modifier approaches and pharmacological therapeutic intervention to rescue microcephaly and neuronal undergrowth caused by Dyrk1a mutations.”

The results of the study unveiled a new mechanism through which Dyrk1a mutations alter growth factor signaling.

“Our results place DYRK1A as a critical regulator of a biological pathway known to be dysregulated in humans with autism spectrum disorder and intellectual disability,” researchers concluded in their study.

Photo: technologynetworks.com

You Might Also Like

Study finds mental distress affects almost half of all teenage females in Norway

ICD-11 lists complex post-traumatic stress disorder as a new condition

New research identifies personality traits linked to cognitive deficits

Many known biological pathways in the brain are impacted by Alzheimer’s disease

Immune system and CNS may play a major role in ALS

TAGGED: Dyrk1a, autism, Genetics
Staff Writer April 8, 2021
Share this Article
Facebook Twitter Whatsapp Whatsapp Email Print
Previous Article Eyesight and hearing impairment may heighten the risk of dementia
Next Article Misogynistic posts on social media linked to violence against women

Recommended

Clinical

Study finds mental distress affects almost half of all teenage females in Norway

1 Min Read
Clinical

ICD-11 lists complex post-traumatic stress disorder as a new condition

1 Min Read
Clinical

New research identifies personality traits linked to cognitive deficits

1 Min Read
Clinical

Many known biological pathways in the brain are impacted by Alzheimer’s disease

1 Min Read
//

We are a trusted online source for research news and resources on all aspects of the mind and human behavior.

Verticals

  • Clinical
  • Health
  • Social
  • I/O
  • Opinion

Social

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Links

  • About
  • Contact
  • Terms & Conditions
  • Privacy Policy
Follow US

© 2022 Mental Daily. All Rights Reserved.

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?