Study shows who may respond well to psychedelics as treatment for mental illness

Over the last several years, many studies have shown just how effective psychedelics are for patients suffering from mental health disorders.

In the journal ACS Pharmacology & Translational Science, certain personality traits were established, which may provide enough insight for researchers to predict how future clinical trial participants will respond to psychedelics as treatment.

The study was conducted at Ohio State University.

According to researchers at Ohio State University, openness to new experiences, along with acceptance and absorption was associated with more positive outcomes while on psychedelics. People who are considered to be apprehensive or preoccupied may have a contrasting outcome.

“The findings point to interesting testable things we can look at in future research,” said one co-author of the study in a press release. “It might be plausible to use threshold doses that are smaller than those used in a trial as a first exposure so people have less anxiety, experience the benefit and, from that, go into a higher dose later.”

“Psychedelics might broadly apply to a whole range of different psychiatric problems, and in part that might be because they’re directly affecting neurotransmission and the brain’s ability to communicate in new ways that involve different parts of the brain,” the author also stated. “But there is still a lot to unpack about exactly how this all works and why it may be effective.”

The study was authored by Jacob Aday, Alan Davis, Cayla Mitzkovitz, Emily Bloesch, and Christopher Davoli.

Image courtesy of David Kovaluk
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