Mental DailyMental Daily
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • The Discussion
    • My Bookmarks
Aa
Mental Daily
Aa
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • Opinion
Search
  • Clinical
  • Health
  • I/O
  • Cybernetic
  • Social
  • More
    • Opinion
    • The Discussion
    • My Bookmarks
Follow US
  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store
© 2022 - Mental Daily. All Rights Reserved.
Clinical

How ketones could be effectual for reducing the severity of Alzheimer’s disease

Staff Writer
Staff Writer 3 years ago
Updated 2019/12/10 at 12:02 AM
Share
SHARE

For patients with Alzheimer’s disease, a ketogenic diet might be effectual for inhibiting the onset of the neurodegenerative condition, according to a new study released in the Journal of Neuroscience.

The study, funded by the National Institute of Health, turned to the examination of rodents, genetically lowering levels of SIRT3.

Among the rodents, a reduction in levels of SIRT3 was associated with an increased rate of mortality, severe seizures, and interneuron death. Interneurons are known to be vulnerable at being wiped out in the neurodegenerative brain by the protein amyloid beta.

“In this study, we examined the function of mitochondrial protein deacetylase sirtuin 3 (SIRT3) in the pathogenesis of AD,” the findings declared. “Compared to AppPs1 mice, Sirt3-haploinsufficient AppPs1 mice (Sirt3+/-AppPs1) exhibit early epileptiform EEG activity and Seizure. Both male and female Sirt3+/-AppPs1 mice were observed to die prematurely before five months of age.”

“When comparing male mice among different genotypes, Sirt3 haploinsufficiency renders GABAergic interneurons in the cerebral cortex vulnerable to degeneration and associated neuronal network hyperexcitability.”

In the findings, the team of researchers uncovered an entirely different end result for rodents exhibiting an abeyance in levels of SIRT3: ketogenic consumption correlated with less instances of seizures and mortality rates, even raising the levels of SIRT3 in the neurodegenerative brain of rodents.

“Consistent with a protective role in AD, SIRT3 levels are reduced in association with cerebral cortical Aβ pathology in AD patients,” the findings concluded.

“In summary, SIRT3 preserves GABAergic interneurons and protects cerebral circuits against hyperexcitability, and this neuroprotective mechanism can be bolstered by dietary ketone esters.”

You Might Also Like

Study finds mental distress affects almost half of all teenage females in Norway

ICD-11 lists complex post-traumatic stress disorder as a new condition

New research identifies personality traits linked to cognitive deficits

Many known biological pathways in the brain are impacted by Alzheimer’s disease

Immune system and CNS may play a major role in ALS

TAGGED: ketones, Alzheimer's disease, cognition
Staff Writer December 9, 2019
Share this Article
Facebook Twitter Whatsapp Whatsapp Email Print
Previous Article Study finds 10% of U.S. adults don’t use the internet
Next Article Study explores how genetic alteration linked to autism & Tourette’s impairs brain communication

Recommended

Clinical

Study finds mental distress affects almost half of all teenage females in Norway

1 Min Read
Clinical

ICD-11 lists complex post-traumatic stress disorder as a new condition

1 Min Read
Clinical

New research identifies personality traits linked to cognitive deficits

1 Min Read
Clinical

Many known biological pathways in the brain are impacted by Alzheimer’s disease

1 Min Read
//

We are a trusted online source for research news and resources on all aspects of the mind and human behavior.

Verticals

  • Clinical
  • Health
  • Social
  • I/O
  • Opinion

Social

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Links

  • About
  • Contact
  • Terms & Conditions
  • Privacy Policy
Follow US

© 2022 Mental Daily. All Rights Reserved.

  • Twitter
  • Facebook
  • Instagram
  • Inc. Profile
  • Google Play Store

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?