“The research involved assessing the memory function in female and male Alzheimer’s mice after they were treated with a drug that selectively blocks a receptor to regulate memory and learning,” according to Khaled Abdelrahman, the study’s first author.
“We then assessed the recovery of memory deficits after treatment and how it is different between sexes. We also examined whether the binding of a toxic Ab; peptide to this receptor is different between male and female mouse and human brain.”
The research led to a drastically effective treatment capable of reversing the neurodegenerative disease, but only in male rodents, the findings claim.
Despite the selective differences, however, the new findings could be of significance for future research of newly developed drugs to combat the commonly diagnosed neurodegenerative disease.
“This will have important implications for future drug discovery and clinical trials design for Alzheimer’s disease,” said Abdelrahman in a news release of the findings.