Connect with us


Opioid Epidemic: FDA Warns About Mixing With Benzodiazepines



Credit: Ron Chapple

Mixing certain sedatives with opioid painkillers could increase the risk of coma or death, the U.S. Federal and Drug Administration warns.

Just when you thought the opioid epidemic couldn’t get any worse, U.S. health officials are now issuing dire warnings for patients who mix the painkiller drugs with certain sedatives, or tranquilizers, including the highly-prescribed benzodiazepines.

More than 389 drug products will soon be receiving a facelift and a “boxed warning” which aims at informing users of its lethal effects when combined with certain sedative drugs, CBS News reported.

According to the FDA, products carrying the new boxed warnings includes opioid drugs such as codeine, oxycodone, and hydrocodone. Additionally, sedatives, with the potential to cause a deadly interaction with the opioid painkillers, will also carry the same boxed warnings; this includes benzodiazepines like Xanax, Ativan, and Klonopin, which act as central nervous system depressants.

Benzodiazepines, like other sedatives, is mainly prescribed to treat anxiety and insomnia. This drug class works by increasing the neurotransmitter GABA, which slows down the central nervous system, inducing excess drowsiness and sleepiness. However, when used in conjunction with opioids, it can increase the risk of respiratory depression, coma or even death.

“After an extensive review of the latest scientific evidence, the U.S. Food and Drug Administration announced today that it is requiring class-wide changes to drug labeling, including patient information, to help inform health care providers and patients of the serious risks associated with the combined use of certain opioid medications and a class of central nervous system (CNS) depressant drugs called benzodiazepines,” the FDA wrote.

The move buy modafinil buy provigil online south africa canada comes after what health officials are calling a ‘significant rise’ in prescriptions by general physicians, causing increased accidental fatal overdoses.

Initially, the opioid panic began in 2014 when a study published by the National Institutes of Health, led by Dr. Brian Site, alarmed health professionals after it found that opioid prescriptions had increased by over 104% just in the past decade.

Although Site’s study was initiated to halt opioid prescriptions, no luck resulted from it as physicians refused to hang their lab coats at the idea that opioids were deadly enough.

However, it wasn’t until the death of music megastar Prince, when the drug crisis received the attention of the public. In April 2016, Prince Rogers Nelson, 57, was found unresponsive in an elevator at his Minnesota home— it was later determined that his cause of death was an accidental opioid overdose, according to an autopsy report.

Prince’s death is just one of many reminders of how dangerous opioid drugs are. The FDA, along with other health organizations, are hard at work to help lower opioid overdoses; they gave the following statement on fixing the epidemic.

“Working with the health care community and federal and state partners to help reduce opioid misuse and abuse and improve appropriate opioid prescribing, while ensuring that patients in pain continue to have appropriate access to opioid analgesics, is a top priority for the FDA and part of HHS’ targeted approach focused on prevention, treatment, and intervention. The agency is committed to continuing to monitor these products and take further actions as needed.”

Jose Florez is the founder of Mental Daily. His work has appeared in Psychology Today, Glamour, The Huffington Post, among others. He is a mental health advocate, and currently studying psychology.

Continue Reading


  1. Mammie

    October 19, 2016 at 3:19 pm

    WebMD notes in its review of the fruit that it might prevent
    fat storage and management appetite.” although the benefits
    still remain inconclusive and uncertain to scientists
    Previous studies show heavy male rats did really slim down from have the substance, while another study that lasted 12 weeks implied that participants
    did lose weight (though there was not a significant reduction in body fat percentage).

  2. garcinia cambogia zt

    October 19, 2016 at 11:32 pm

    Garcinia Cambogia has some medicinal uses, as its
    infusion is used in many traditional medicines largely to improve digestion.

  3. plans building furniture

    October 20, 2016 at 6:01 am

    Wonderful article! We will be linking to this great content on our site.
    Keep up the good writing.

  4. room seem

    October 20, 2016 at 7:07 am

    At this time I am going away to do my breakfast, afterward having my breakfast coming over again to read more news.

  5. think funny

    October 20, 2016 at 12:43 pm

    What’s up Dear, are you genuinely visiting this site daily,
    if so afterward you will definitely get good experience.

  6. book a stand up comic

    October 20, 2016 at 1:14 pm

    Thanks for sharing your thoughts. I really appreciate
    your efforts and I am waiting for your next write ups thanks once again.

  7. truly funny

    October 20, 2016 at 4:33 pm

    What’s up, for all time i used to check website posts here early in the daylight, since i love to find out more and more.

  8. Crowd Fund Social

    October 20, 2016 at 4:50 pm

    I love it when folks come together and share ideas.
    Great website, keep it up!


    October 20, 2016 at 11:25 pm

    whoah this weblog is great i really like reading your articles.
    Keep up the good work! You realize, lots of people are hunting around for this info, you can help them greatly.

  10. Pingback: Young Children Are Being Poisoned By Opioid Prescriptions

Leave a Reply

Your email address will not be published. Required fields are marked *

Like Us