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Major Depressive Disorder

Classification: Depressive Disorder

ICD-9-CM Code: 296.21 (mild), 296.22 (moderate), 296.23 (severe), 296.24 (w/ psychosis), 296.25 (in partial remission), 296.26 (in full remission), 296.20 (unspecified)

ICD-10-CM Code: F32.9

Symptoms: Diminished loss of interest or pleasure in activities for most of the day; Fatigue or loss of energy; Insomnia or hypersomnia; Psychomotor agitation or retardation; Decreased concentration and decisiveness; Significant weight loss or increased appetite; Recurrent thoughts of suicide or death.

* Impaired functioning in major areas such as work, school, interpersonal relations, and self-care.


  • with anxious distress
  • with mixed features
  • with melancholic features
  • with atypical features
  • with mood-congruent psychotic features
  • with mood-incongruent psychotic features
  • with catatonia
  • with peripartum onset
  • with seasonal pattern

Usual Onset: Early Adulthood

Comorbidity: Disruptive Mood Dysregulation Disorder, Oppositional Defiant Disorder, Anxiety Disorders, Substance Use Disorders

Gender Ratio: Women > Men


  • Antidepressants
  • Antipsychotics
  • Benzodiazepines
  • Interpersonal Psychotherapy
  • Cognitive Behavioral Therapy
  • Rational Emotive Behavior Therapy
  • Mindfulness-Based Cognitive Therapy
  • Psychodynamic Psychotherapy
  • Electroconvulsive Therapy
  • Transcranial Magnetic Stimulation
  • Light Therapy
  • Physical Exercise

Synonyms: Major depression, clinical depression, unipolar depression, unipolar disorder, recurrent depression


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